Stable chronic obstructive pulmonary disease (COPD)
Conditions
Interventions
aerobic exercise rehabilitation group:aerobic exercise rehabilitation
Resistance exercise group:Home-based upper- and lower-limb elastic-band resistance exercise
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the GOLD diagnostic criteria for stable chronic obstructive pulmonary disease (COPD); 2. Post-bronchodilator pulmonary function classified as GOLD stage II or III, with 30% <= FEV1% predicted <80%; 3. Aged 40 to 80 years; 4. Able to understand the study and voluntarily provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Other major pulmonary diseases affecting study assessment or exercise rehabilitation, including interstitial lung disease, pulmonary fibrosis, pneumoconiosis, active tuberculosis, or lung cancer; 2. Acute respiratory failure, decompensated chronic respiratory failure, or other acute or unstable respiratory conditions; 3. Severe cardiovascular disease, including unstable angina, acute myocardial infarction within 3 months, heart failure, uncontrolled severe arrhythmia, or severe valvular disease; 4. Severe hepatic, renal, or other major organ dysfunction; 5. Other malignancies, limb dysfunction, fracture, or other conditions preventing exercise rehabilitation; 6. Severe cognitive impairment; 7. Poorly controlled metabolic disease; 8. Recent systemic corticosteroid use for acute exacerbation, current immunosuppressive treatment, biologic or immunomodulatory therapy, or long-term anti-rejection therapy after organ transplantation; 9. Participation in or receipt of any pulmonary rehabilitation program within the previous 6 months; 10. Any other condition considered unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in the 6-minute walk distance (6MWD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum irisin level and change from baseline;Change from baseline in the modified Medical Research Council (mMRC) dyspnea score;Occurrence of COPD exacerbations during the 1-year follow-up after completion of the 8-week intervention;Change from baseline in the Chronic Airways Assessment Test (CAAT) score;Change from baseline in pulmonary function parameters; | — |
Countries
China
Contacts
Public ContactAihong Meng
The Second Hospital of Hebei Medical University
Outcome results
None listed