depression
Conditions
Interventions
Experimental group:Accelerated Repetitive Transcranial Magnetic Stimulation Combined with Fluoxetine
Control group:sham Stimulation Combined with Fluoxetine
Sponsors
General Hospital of Northern Theater Command
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 13 to 18 years, Han ethnicity. 2. Diagnosed with major depressive disorder according to the Structured Clinical Interview for the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (SCID-5), consistent with DSM-5 diagnostic criteria. 3. Baseline total score of the Chinese version of Adolescent Anhedonia Scale (ASA-C) >= 21 points; a total score greater than 21 points was defined as significant anhedonia. 4. Baseline total score of the 24-item Hamilton Depression Rating Scale (HAMD-24) >= 20 points. 5. No antidepressant medication used within 3 months before enrollment. For participants with previous medication history, a washout period of at least five drug half-lives was required. 6. Able to complete the whole course of intervention and follow-up, and cooperate with scale evaluation and peripheral blood collection.
Exclusion criteria
Exclusion criteria: 1. Complicated with bipolar disorder, schizophrenia spectrum disorders, autism spectrum disorder, severe conduct disorder or substance use disorders. 2. A history of epilepsy, febrile convulsions, intracranial and extracranial trauma, intracranial metal implants or cardiac pacemaker implantation, or presence of absolute contraindications to transcranial magnetic stimulation. 3. Continuous use of immunosuppressants, glucocorticoids or non-steroidal anti-inflammatory drugs for more than 7 days within 2 weeks before enrollment; combined with chronic autoimmune inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. 4. Severe physical diseases: uncontrolled thyroid dysfunction, chronic liver and renal failure, hematological diseases; acute infection within 4 weeks prior to enrollment. 5. Female adolescents with menstrual disorders and unprotected sexual behavior. 6. Received repetitive transcranial magnetic stimulation (rTMS), modified electroconvulsive therapy (ECT), or transcranial direct current stimulation (tDCS) within 6 months before enrollment. 7. The score of the suicide item on the 24-item Hamilton Depression Rating Scale (HAMD-24) was 3 at screening (indicating high suicide risk), requiring urgent electroconvulsive therapy or inpatient crisis intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale-24;Chinese Version of the Anhedonia Scale for Adolescents; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wisconsin Card Sorting Test;IL-1ß;IL-6;TNF-a; | — |
Countries
China
Contacts
Public ContactWang Qi
General Hospital of Northern Theater Command
Outcome results
None listed