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Vitamin D Deficiency and Postoperative Cognitive Dysfunction

Causal Association and Mechanisms Between Vitamin D Deficiency and Postoperative Cognitive Dysfunction in Elderly Cancer Surgery Patients: A Mendelian Randomization Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600129713
Enrollment
Unknown
Registered
2026-08-08
Start date
2024-11-15
Completion date
Unknown
Last updated
2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

Observation group:None

Sponsors

Peking University First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients aged 65 years and older undergoing elective non-cardiac, non-oncological surgery; 2. The anticipated duration of the surgery exceeds 2 hours; 3. All subjects received standard intraoperative monitoring (e.g., heart rate, blood pressure, pulse oxygen saturation, depth of anesthesia, etc.). 4. The subject provides informed consent and signs the informed consent form.

Exclusion criteria

Exclusion criteria: 1. A history of diagnosed mental or neurological disorders, including senile dementia, schizophrenia, etc.; 2. American Society of Anesthesiologists (ASA) Physical Status Classification Class IV or higher; 3. History of alcohol or substance abuse; 4. Visual and hearing impairments.

Design outcomes

Primary

MeasureTime frame
Postoperative Cognitive Dysfunction;—

Secondary

MeasureTime frame
Inflammatory factor IL-6;Vitamin D;—

Countries

China

Contacts

Public ContactMa Jiahui

Peking University First Hospital

mjh@bjmu.edu.cn+86 10 83575085

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 25, 2026