depression
Conditions
Interventions
low dose ECT group:low dose ECT
standard dose ECT group:standard dose ECT
External Control Group:antidepressant
Sponsors
Beijing Huilongguan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Meets the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th edition) diagnostic criteria for a depressive episode; 2.Aged 60–85 years; 3.Hamilton Depression Rating Scale (17-item, HAMD-17) score > 17; 4.The patient and their family members voluntarily participate and sign the informed consent form; 5.No contraindications for electroconvulsive therapy (ECT); 6.No color blindness or physical disabilities that would interfere with cognitive function testing; 7.Educational level of primary school or above.
Exclusion criteria
Exclusion criteria: 1.Other mental disorders meeting the DSM-5 diagnostic criteria, such as dementia, schizophrenia, etc. 2.Definite history of epileptic seizures or delirium tremens; 3.History of dependence on stimulants, narcotics, or sedative-hypnotics; 4.Severe or unstable medical conditions; 5.Concurrent use of other medications that may affect efficacy evaluation, such as benzodiazepines, neuroleptics, etc. 6.Contraindications for MRI scanning; 7.Receipt of other physical or psychological treatments affecting cognitive function within the past 6 months.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Repeatable Battery for the Assessment of Neuropsychological Status;Charlson Comorbidity Index;Clinical Global Impression Score;Hamilton Anxiety Scale Score;subject memory;Brain structure and functional MRI indicators;Self-rating Idea of Suicide Scale Score;Incidence of adverse events and reactions;Chinese version of the Mini-Mental State Examination (MMSE) Score;Montreal Cognitive Assessment Score; | — |
Primary
| Measure | Time frame |
|---|---|
| 17-item Hamilton Depression Rating Scale; | — |
Countries
China
Contacts
Public ContactCai Haipeng
Beijing Huilongguan Hospital, Capital Medical University
Outcome results
None listed