Scoliosis:Uneven
Conditions
Interventions
Group E: Esketamine Group (n=30). Patients received esketamine combined with total intravenous anesthesia (TIVA).:When the TOF reaches 90%, group E is given an infusion of esketamine (continuously at
Group C: Control Group (n=30). Patients received standard TIVA protocol.:When TOF reaches 90%, infuse an equal amount of saline and stop when the surgery starts closing.
Group D: Dexmedetomidine Group (n=30). Patients received dexmedetomidine combined with total intravenous anesthesia (TIVA).:When TOF reaches 90%, Group D pumps in dexmedetomidine (0.5 µg/kg/h) until t
Sponsors
The Third Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
14 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. The patient and their family members were fully informed and voluntarily agreed to participate in the study, and provided written informed consent; 2. Age 14-30 years (according to the *Medium- and Long-Term Youth Development Plan (2016-2025)* issued by the State Council, the youth age range is defined as 14-35 years); 3. ASA physical status classification I-II; 4. Scheduled to undergo elective scoliosis surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Presence of preoperative neurological compression symptoms; 2. Intraspinal abnormalities including syringomyelia; exclusion of spinal cord injury, diastematomyelia, and spinal cord embolism based on preoperative magnetic resonance imaging (MRI) findings; 3. Anticipated difficult airway; 4. History of epilepsy; 5. Intracranial hypertension; 6. Contraindications to any medication used in the study, including esketamine, dexmedetomidine, propofol, remifentanil, cisatracurium, etc.; 7. Concurrent participation in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The changes in transcranial motor evoked potential (TcMEP) amplitude recorded from the left tibialis anterior muscle.;The total amounts of propofol, sufentanil, and remifentanil administered during the surgery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in TcMEP and CSEP amplitudes at the right TA, bilateral TM, RA, IP, AM, QF, and PT muscles.;Postoperative anxiety and depression assessment scores;Postoperative sleep quality score;Postoperative pain scores; | — |
Countries
China
Contacts
Public ContactZhang Zheng
The Third Affiliated Hospital Sun Yat-sen University
Outcome results
None listed