Patients with preoperative anxiety prior to gallbladder stone surgery
Conditions
Interventions
Experimental Group:Administer dexmedetomidine hydrochloride nasal spray
control group:Give an equal volume of normal saline.
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Have a full understanding of the purpose and significance of this trial, voluntarily participate in this clinical trial, and voluntarily sign the informed consent form; 2.Patients undergoing elective laparoscopic cholecystectomy under general anesthesia, with an expected surgical duration of =7;
Exclusion criteria
Exclusion criteria: 1.Subjects deemed unsuitable for intranasal administration (e.g., those with severe rhinitis or nasal deformities); 2.Subjects with a history of myocardial infarction or unstable angina; subjects with sick sinus syndrome or severe bradycardia (HR < 30%); 3.Subjects with a history of ischemic stroke or transient ischemic attack; 4.Subjects with poorly controlled blood pressure despite medication; 5.Subjects with a history of psychiatric disorders, cognitive impairment, or epilepsy; 6.Patients with sleep apnea syndrome or a history of airway obstruction; 7.Patients with a history of major surgery, such as cardiac or great vessel surgery, or major organ transplantation (thoracic or abdominal); 8.Subjects with a history of drug abuse, substance abuse, or alcoholism; 9.Patients on long-term sedatives or analgesics; those who have used adrenergic receptor agonists or antagonists prior to randomization; 10.Subjects with coagulation disorders, thyroid dysfunction, or abnormal baseline test results; 11.Subjects with allergies to the drug’s active ingredients or components; 12.Pregnant or breastfeeding women; subjects planning to become pregnant within the specified timeframe and not using contraception; 13.Subjects who have participated in other drug clinical trials (and received investigational drugs) within the past 6 months; 14.Other circumstances deemed by the investigator to make the subject unsuitable for participation in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Preoperative Anxiety Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain Score;Peroperative Sleep Quality Score;Restore Quality Score Check;Incidence of Adverse Reactions; | — |
Countries
China
Contacts
Public ContactHu Haijie
West China Hospital of Sichuan University
Outcome results
None listed