Postoperative Atrial Fibrillation (POAF)
Conditions
Interventions
Placebo group:Continuous intravenous infusion of 0.9% normal saline
Magnesium Sulfate group:Continuous Intravenous Magnesium Sulfate Infusion
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18–85 years scheduled for elective isolated coronary artery bypass grafting (CABG) under cardiopulmonary bypass; 2. Preoperative heart rate >=50 beats per minute (bpm), with sinus rhythm or correctable cardiac arrhythmias; 3. Provision of signed informed consent, with the ability to understand the study procedures and a willingness to participate voluntarily. 4. Preoperative serum magnesium levels within the normal range (0.75–1.05 mmol/L). 5. No contraindications to the planned surgical procedures or standard perioperative management.
Exclusion criteria
Exclusion criteria: 1. Patients scheduled for emergency or urgent cardiac surgery; 2. Combined cardiac procedures (e.g., CABG combined with valve surgery, double or multiple valve surgery, or great vessel surgery); 3. Redo cardiac surgery (history of prior cardiac surgery via thoracotomy); 4. History of atrial fibrillation or other cardiac arrhythmias; 5. Preoperative hemodynamic instability (e.g., cardiogenic shock, dependence on continuous intravenous vasopressors to maintain blood pressure, or preoperative use of mechanical circulatory support such as IABP or ECMO); 6. Severe baseline hypotension (e.g., systolic blood pressure = 40 kg/m².
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of new-onset postoperative atrial fibrillation (POAF) within the first 5 postoperative days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of postoperative atrial fibrillation;ICU and hospital length of stay;Serious adverse events (SAEs) such as postoperative hypotension and heart rate abnormalities; | — |
Countries
China
Contacts
Public ContactChanghong Miao
Zhongshan Hospital, Fudan University
Outcome results
None listed