Traumatic Brain Injury
Conditions
Interventions
Remifentanil conventional analgesia group (Rcag):Remifentanil conventional analgesia.
Nambuphine combined with remifentanil multimodal analgesia group (NRmag):Nambuphine combined with remifentanil multimodal analgesia.
Sponsors
Shanghai Pudong New Area Gongli Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-75 years old; 2.Expected stay in ICU for >= 48 hours; 3.Closed or penetrating traumatic brain injury, with a GCS score of 3-12 after resuscitation, requiring analgesic and sedative treatment; 4.Obtain informed consent from patients or family members.
Exclusion criteria
Exclusion criteria: 1.Brain stem injury, bilateral dilation of pupils, late stage brain herniation, postoperative shock or brain death, etc; 2.Blood pressure <= 90/60 mmHg; 3.Severe liver and kidney dysfunction; 4.Sinus bradycardia and second degree or above atrioventricular block; 5.Taking psychotropic drugs; 6.During the observation period, it is necessary to use benzodiazepines to control the occurrence of epilepsy; 7.Pregnancy or breastfeeding; 8.Known to be allergic to any investigational drug; 9.Risk period intestinal obstruction (present or at risk of progression to gastrointestinal obstruction, especially in patients with paralytic intestinal obstruction).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First bowel movement time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to recovery of bowel sounds;Timing of enteral nutrition initiation;AGI Score;CAM-ICU Score;GCS Score;SOFA Score;APACHE? Score;CPOT Score;RASS Score;Vital signs (H&MAP&R&SpO2); | — |
Countries
China
Contacts
Public ContactQiancheng Luo
Shanghai Pudong New Area Gongli Hospital
Outcome results
None listed