Postoperative sleep disorder
Conditions
Interventions
Dexmedetomidine Group:Intravenous infusion of dexmedetomidine at 0.5 µg/kg 10 minutes before anesthesia induction
during the maintenance phase of anesthesia, intravenous infusion of dexmedetomidine at 0.3 µg/kg/h (discontinued 30 minutes before the end of surgery).
Normal saline Group:Intravenous infusion of normal saline at an equivalent volume to the dexmedetomidine group 10 minutes before anesthesia induction
during the maintenance phase of anesthesia, intravenous infusion of normal saline at an equivalent volume to the dexmedetomidine group (discontinued 30 minutes before the end of surgery).
Sponsors
Jinling Hospital, Affiliated with Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA physical status I-III; 2.Aged 18 to 65 years; 3.Undergoing elective urological laparoscopic surgery; 4.Fully understand the trial procedures and voluntarily participate, with signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Preoperative sleep disturbance with a Pittsburgh Sleep Quality Index (PSQI) score > 7; 2.Preoperative anxiety or depression with a Hospital Anxiety and Depression Scale (HADS) score > 6; 3.Severe cardiac insufficiency, severe hepatic insufficiency (Child-Pugh class C), or renal failure; 4.Long-term use of opioids, sedatives, antidepressants, or anxiolytics; 5.History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis; 6.Inability to communicate effectively, inability to cooperate with sleep assessment, or refusal to participate in the study; 7.Inability to use a patient-controlled intravenous analgesia (PCIA) pump postoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sleep disturbance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in patients' peri?operative electroencephalogram;Visual Analogue Scale Score;Postoperative opioid use; | — |
Countries
China
Contacts
Public ContactShen,Jin-chun
Jinling Hospital, Affiliated with Nanjing University Medical School
Outcome results
None listed