Postoperative Delirium (POD) is an acute, fluctuating and reversible mental disorder that occurs in patients after surgery, mainly manifested as confusion, inattention, cognitive dysfunction, hallucinations, disorientation, etc. The incidence rate is approximately 2.5% to 3.0% in general surgeries, while it can be as high as 20% to 70% in high-risk surgeries (such as heart surgeries and emergency
Conditions
Interventions
Control group:intravenous injection of saline
Intrervention group:Intravenous injection of dexamethasone
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Scheduled for elective major abdominal surgery under general anesthesia. 2.Patients aged 65 years or older; 3.American Society of Anesthesiologists (ASA) physical status I–III. 4.Expected surgical duration >=1 hour. 5.Written informed consent obtained.
Exclusion criteria
Exclusion criteria: 1.Emergency surgery, day-case surgery, cardiac surgery, or neurosurgery. 2.Poorly controlled diabetes mellitus, defined as glycated hemoglobin (HbA1c) >9.0%. 3.History of neurological or psychiatric disorders, or long-term use of sedative, antidepressant, or hypnotic medications. 4.Preoperative cognitive impairment,or inability to complete cognitive assessment due to hearing impairment, language barriers, or other reasons. 5.Systemic glucocorticoid use within 3 months before enrollment; surgery within 3 months before enrollment; or history of peptic ulcer disease. 6.History of alcohol or drug abuse. 7.Pregnancy or breastfeeding. 8.BMI > 28.0 kg/m^². 9.Any condition judged by the investigators to make the patient unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative comfort level;PONV;Postoperative pain;Fasting Blood Glucose; | — |
Countries
China
Contacts
Public ContactYan Luo
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed