Malignant tumors
Conditions
Interventions
Index test:18F-FDG Total-body PET/CT delayed imaging.All participants will receive a single injection of 18F-FDG (3.7 MBq/kg) and undergo Total-body PET/CT imaging at 60 minutes and 6 hours after inje
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 80 years, with no restriction on sex; 2.Patients with clinically suspected or newly diagnosed tumors who are scheduled to undergo PET/CT for diagnosis and staging; tumor patients who are scheduled to undergo PET/CT for follow-up or suspected recurrence and restaging; or tumor patients who are scheduled to undergo PET/CT for response evaluation after systemic treatment; 3.Patients who can provide a definitive pathological diagnosis before or after PET/CT examination, with an interval of no more than 4 weeks between pathological diagnosis and PET/CT examination, and who have not received anti-tumor treatment during this interval; 4.Women of childbearing potential with no pregnancy plan within 3 months; 5.Patients with good compliance, clear consciousness, and the ability to move and take care of themselves; 6.A stratified enrollment strategy will be adopted, with approximately 5%-10% of the total enrolled participants being high-BMI patients (BMI >29 kg/m²); 7.Participants who agree to participate in this clinical study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Poor general condition and inability to cooperate with the examination; 2.Mental disorders or intellectual developmental delay resulting in poor compliance and inability to cooperate with the examination; 3.Fasting blood glucose >=11 mmol/L; 4.Pregnant women; 5.Patients with claustrophobia; 6.Other conditions deemed by the investigators to be unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion detection sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Background-tissue standardized uptake values and standard deviation (SUVmax, SUVmean, and SD);Background image signal-to-noise ratio;Five-point visual score for lesion 18F-FDG uptake;Retention index of lesion 18F-FDG uptake;Interobserver agreement;Lesion-to-background ratios;Number and rate of detected malignant lesions;Lesion standardized uptake values (SUVmax, SUVpeak, and SUVmean); | — |
Countries
China
Contacts
Public ContactShi Hongcheng
Zhongshan Hospital, Fudan University
Outcome results
None listed