Keloids: Changes in the appearance and histology of normal skin tissue caused by various skin injuries. They appear raised above the normal skin surface, extend beyond the original injury area, and continue to grow, sometimes accompanied by itching or pain.
Conditions
Interventions
Conventional fractionation group (4Gy×5):None
Large fractionation group (5Gy×4):None
Sponsors
China National Nuclear Corporation 416 Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–80, any gender; 2.Clinically and pathologically confirmed keloids, with complete surgical removal; 3.Time from surgery to first radiotherapy <= 24 hours; 4.Radiotherapy using 6–9 MeV electron beams, total dose 20Gy; 5.Complete follow-up data, with last follow-up at least 12 months after surgery.
Exclusion criteria
Exclusion criteria: 1.Did not receive radiotherapy promptly after surgery; 2.Severe diabetes complications, autoimmune skin diseases, or history of malignant tumors; 3.Pregnant or breastfeeding women; 4.Keloid area has acute infection or poor wound healing;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The recurrence rate of keloids (defined as the appearance of skin elevation, congestion or obvious itching/pain beyond the original incision edge within the surgical incision range during the follow-up period, and it persists for more than one month without subsiding); | — |
Secondary
| Measure | Time frame |
|---|---|
| Vancouver Scar Scale (VSS) score (evaluating color, thickness, vascular distribution and softness);Patient-reported pain and pruritus score (VAS);RTOG skin injury classification (Evaluation of acute and late radiation-induced skin injury); | — |
Countries
China
Contacts
Public ContactYu Daojiang
China National Nuclear Corporation 416 Hospital
Outcome results
None listed