Intracerebral hemorrhage
Conditions
Interventions
Intervention group:Diluted epinephrine saline irrigation
Sponsors
Changsha Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years and <= 75 years, irrespective of gender; 2. Patients who have undergone external ventricular drainage for therapeutic indications (e.g., intracerebral hemorrhage, hydrocephalus, etc.) and are planned for bedside extubation of the ventricular catheter; 3. Written informed consent has been obtained from the patient or their legally authorized representative.
Exclusion criteria
Exclusion criteria: 1.Hypersensitivity to epinephrine or any of its excipients; 2. Uncorrectable coagulopathy or thrombocytopenia prior to extubation, defined as INR > 1.5, or platelet count < 75 × 10^9/L; 3. Malposition of the ventricular catheter with the tip failing to reach the ventricular cavity, resulting in absent or inadequate cerebrospinal fluid drainage, thus making diluted epinephrine saline irrigation inapplicable; 4. Active hemorrhage along the puncture route or within the ventricular system, or a marked increase in intracranial hematoma volume on pre-extubation CT; 5. Concurrent severe comorbidities that might confound the assessment of safety and efficacy, or a life expectancy of less than 48 hours; 6. Family decision to withdraw active treatment and request tube removal for transfer or discharge, with refusal of routine post-extubation head CT; 7. Pregnancy or lactation; 8. Adrenal disorders; 9. History of malignant cardiac arrhythmias, including ventricular fibrillation, sustained ventricular tachycardia, and Wolff-Parkinson-White syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hemorrhage after drain removal;Incidence of intracranial infection after drain removal;Vital signs after drain removal; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of secondary intervention due to rebleeding after drain removal;Incidence of headache after drain removal;Incidence of nausea and vomiting after drain removal; | — |
Countries
China
Contacts
Public ContactHuang Yunfeng
Changsha Central Hospital
Outcome results
None listed