Frailty
Conditions
Interventions
Intervention group (Lower limb blood flow restriction enhanced multi-component exercise):12-week lower limb blood flow restriction enhanced multi-component exercise (3 times per week, 45-60 minutes pe
including resistance, aerobic, balance, gait, and flexibility training)
Control group (Health education + routine follow-up):Health education and routine follow-up (elderly health, exercise safety, fall prevention, nutritional support, chronic disease self-management
no structured supervised exercise training provided, no lower limb blood flow restriction training scheduled)
Sponsors
Guangzhou Sport University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=60 years old; 2. Gender is not limited; 3. Residence status: Elderly residents in the community, who can travel to and from the experimental site by themselves or with assistance. 4. Frailty status: Fried frailty phenotype score >=1 point (including pre-frailty and frailty). 5. There are no acute phase diseases or severe decompensation states. The current condition has been evaluated by clinical doctors as relatively stable 6. No contraindications for exercise; 7. No color blindness, mental illness, etc. 8. Be able to understand the research content, be willing to participate in this study and sign the written informed consent form
Exclusion criteria
Exclusion criteria: 1.Acute illness or severe decompensated conditions, such as acute infections, early postoperative period after major surgery, uncontrolled heart failure, severe hypertension, or poorly controlled diabetes with metabolic decompensation; 2.Marked cognitive impairment or severe mental disorders that make it impossible to understand study information or comply with the intervention and assessments; recent intracranial injury, intracranial hemorrhage, or intracranial surgery still in the recovery phase, as well as other neurological diseases requiring strict intracranial pressure control; 3.Presence of important implanted devices or other contraindications to exercise/aquatic training, and judged by relevant specialists to be unsuitable for moderate-intensity exercise or aquatic training; 4.Specific contraindications to aquatic training: poorly controlled epilepsy or syncope tendency, large open wounds or active skin infections, uncontrolled urinary or fecal incontinence, active infectious diseases requiring isolation, or a history of severe allergy to swimming pool disinfectants; 5.Marked fear of water, with persistent inability to relax in shallow water after explanation and trial exposure, making it difficult to safely complete basic water walking and exercises; 6.Any other obvious safety concerns or conditions judged by the investigators to seriously affect adherence to the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Short Physical Performance Battery (SPPB) total score at 12 weeks;Ankle-brachial index and peripheral arterial stiffness parameters (ABI, baPWV, cfPWV);Central arterial pressure and wave reflection indices (central systolic/diastolic pressure, augmentation index);Brachial artery flow-mediated dilation (FMD) and shear rate–normalized FMD;Middle cerebral artery blood flow velocity and dynamic cerebral autoregulation indices (phase, gain via transfer function analysis);Montreal Cognitive Assessment–CHINA version (MoCA-BC) total score;Heart rate variability (HRV) parameters in time and frequency domains;SF-36 health-related quality of life scores (domain and summary scores); | — |
Secondary
| Measure | Time frame |
|---|---|
| Senior Fitness Test (SFT) component performance;6-minute walk distance and spatiotemporal gait parameters; | — |
Countries
China
Contacts
Public ContactXia Jingbo
Guangzhou Sport University
Outcome results
None listed