Rheumatoid arthritis
Conditions
Interventions
RA patient group:None
Healthy volunteer group:None
Sponsors
Taicang Loujiang New City Hospital (Ruijin Hospital, Taicang)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Bioinformatics analysis datasets 1. Synovial tissue samples from patients with a definite diagnosis of rheumatoid arthritis; 2. Datasets containing complete gene expression profiling data; 3. Datasets with clear grouping information for RA group and normal control group. Clinical samples 1. RA patients meeting the 2010 ACR/EULAR classification criteria; 2. Healthy volunteers with no history of autoimmune diseases; 3. All subjects have signed informed consent forms.
Exclusion criteria
Exclusion criteria: 1.Bioinformatics analysis datasets (1) Samples with unqualified data quality; (2) Samples lacking clear grouping information. 2.Clinical samples (1) Comorbid with other autoimmune diseases; (2) Recent use of immunosuppressive therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of hub genes (PTPN6, CASP1, CD47) and their ability to discriminate RA from control samples (based on area under the receiver operating characteristic curve, AUC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Differentially Expressed Endothelial-Related Genes (DE-ERGs) screening results;Immune cell infiltration score;Prediction of miRNAs and transcription factors (TFs);qRT-PCR validation results;Phagocytic clearance-related indicators (CFSE-positive proportion, p-MerTK, Calreticulin, IL-1ß); | — |
Countries
China
Contacts
Public ContactLiu Zhenlu
Taicang Loujiang New City Hospital (Ruijin Hospital, Taicang)
Outcome results
None listed