Depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age range: 12 - 18 years old. 2. Gender: No restrictions. 3. Patients with depression who meet the DSM-V criteria for unipolar depressive disorder (diagnosed by M.I.N.I.). 4. HAMD score >= 17 points. 5. No use of antipsychotic drugs or mood stabilizers in the previous 3 months. 6. Voluntary participation and informed consent from legal guardians. 7. Adequate cultural and visual comprehension to understand the research content.
Exclusion criteria
Exclusion criteria: 1. There are other mental disorders apart from severe depressive disorder. 2. Substance or alcohol abuse disorder. 3. Severe or unstable physical diseases. 4. Abnormal laboratory tests with clinical significance. 5. Pregnancy. 6. High risk of severe suicide (suicide attempts within one year or moderate or above on the "suicide" item of the Hamilton Depression Rating Scale (HAMD)). 7. Received electroconvulsive therapy or repetitive transcranial magnetic stimulation within the last month. 8. Currently undergoing other psychological treatments. 9. Used antibiotics, non-steroidal anti-inflammatory drugs, or other drugs that affect the results within the last 10. The Mood Disorder Questionnaire (MDQ) is positive.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of decrease in HAMD score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-International Neuropsychiatric Interview for Children and Adolescents;Heart Rate Variability;Patient Health Questionnaire-9;Children’s Depression Inventory;Generalized Anxiety Disorder-7;Screen for Child Anxiety Related Emotional Disorders;Revised Children’s Anxiety and Depression Scale - 25;Mood Disorder Questionnaire;Young Mania Rating Scale ;Snaith-Hamilton Pleasure Scale;Patient Health Questionnaire-15;Pittsburgh Sleep Quality Index;Ottawa Self-injury Inventory;Three Questions for Suicide Risk Screening;Young's Diagnostic Questionnaire for Internet Addiction;Smartphone Addiction Scale - Short Version;Adolescent Self-Rating Life Events Checklist;Childhood Trauma Questionnaire - Short Form;Perceived Stress Scale-10;Self-rating Scale of Systemic Family Dynamics;Adolescent Social Support Scale Chinese version; Egna Minnen Barndoms Uppfostran;Inventory of Parent and Peer Attachment;Children’s Perception of Interparental Conflict;Connor-Davidson Resilience Scale;UCLA Loneliness Scale (Version 3);Basic Empathy Scale-Chinese Version;Chinese Revised Spontaneity Assessment Inventory;Interpersonal Emotion Regulation Questionnaire;Emotion Regulation Questionnaire;Chinese Version of the Brief form of Interpersonal Competence Questionnaire;Hamilton Anxiety Rating Scale;Yale-Brown Obsessive Compulsive Scale;Children’s Global Assessment Scale;Working Alliance Inventory-Short Version;Revised Children’s Anxiety and Depression Scale - 25(for parents);Patient Health Questionnaire-15;Parent–child relationships scale;Social Support Rating Scale;Revision of the Short-form Egna Minnen av Barndoms Uppfostran for Chinese;Self-Rating Life Events Checklist;Child Behavior Checklist;General Self-efficacy Scale;Appraisal of Life Quality;Hamilton Depression Rating Scale; | — |
Countries
China
Contacts
Shanghai Sixth People's Hospital