Respiratory diseases
Conditions
Interventions
Group O (aged 75 and above): Group O (75 and older), the first patient got 30 µg/kg. Ffollowing the Dixon up-and-down method. If a patient had a reaction during intubation, the next patient would get
Group Y (aged 65-74):For Group Y (ages 65-74), the first patient received a dose of 40 µg/kg of Teglityl. Following the Dixon up-and-down method. If a patient had a reaction during intubation, the nex
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged 65 or above, regardless of gender; 2.BMI ranging from 18 to 28 kg/m^2; 3. ASA classification of grade I or II; 4.Patients who plan to undergo tracheal intubation under general anesthesia; 5.Participants voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients known to be allergic to teligliflozin or its components. 2.Patients with expected difficult airways. 3. Patients with severe hypertension (systolic blood pressure >= 180 mmHg, or diastolic blood pressure >= 110 mmHg). 4. Patients with severely impaired liver and kidney function (Child-Pugh C grade, or eGFR 2 weeks).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED95 of tegilidine for attenuating the tracheal intubation response in elderly patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| ED50 of tegilidine for attenuating the tracheal intubation response in elderly patients;Use of vasoactive drugs;Adverse events; | — |
Countries
China
Contacts
Public ContactBailong Hu
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed