pancreatic cystic neoplasms
Conditions
Interventions
Experimental group: EUS guided lauromacrogol ablation
control group: EUS?guided saline lavage combined with paclitaxel and gemcitabine ablation
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Imaging diagnosis of mucinous cystic neoplasm (MCN) or PCN with associated symptoms (jaundice, pancreatitis, abdominal pain, etc. caused by compression of the common bile duct, main pancreatic duct, or gastrointestinal tract), or PCN whose nature cannot be determined by imaging; 2. Aged 18–85 years.
Exclusion criteria
Exclusion criteria: 1. Patients who were readmitted during the study period to undergo EUS ablation; 2. Patients with >=6 cysts; 3. Patients with a pancreatic cystic neoplasm (PCN) communicating with the main pancreatic duct; 4. Patients in whom the possibility of malignancy cannot be ruled out (presence of wall nodules, solid components, eggshell-like calcifications in the wall, cytology of cyst fluid suggestive of malignancy or high-grade dysplasia, main pancreatic duct dilation >10 mm, or symptoms caused by the condition); 5. Acute pancreatitis or signs of pancreatic necrosis; pancreatic pseudocysts; 6. Contraindications to EUS; contraindications to anesthesia; contraindications to paclitaxel, poliglavonol, or gemcitabine; 7. Other conditions deemed by the investigator to render the patient unsuitable for enrollment, or a short life expectancy; 8. Pregnant or breastfeeding women; 9. Patients with coagulation disorders; 10. Patients who are unwilling or unable to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| resolved rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| complication rate;complete resolved rate;partial resolved rate;Diabetes mellitus rate;pancreatic cancer rate;Incidence of symptoms such as abdominal pain and jaundice;Length of Hospital Stay and Costs; | — |
Countries
China
Contacts
Public ContactChai Ningli
Chinese PLA General Hospital
Outcome results
None listed