Bronchial asthma, severe allergic reaction
Conditions
Interventions
The group of children with asthma and severe anaphylaxis:None
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
5 Years to 16 Years
Inclusion criteria
Inclusion criteria: 1. From March 2023 to March 2026, children aged 5–16 years diagnosed with severe anaphylaxis and treated with omalizumab at the First Affiliated Hospital of Xi'an Jiaotong University were enrolled as study subjects. 2. According to the 2021 Chinese recommendations for the diagnosis and treatment of pediatric anaphylaxis, the diagnostic criteria for anaphylaxis are as follows: (1) acute onset of skin and/or mucosal symptoms within minutes to hours, accompanied by at least one of the following: respiratory symptoms, hypotension or end-organ dysfunction, or severe gastrointestinal symptoms; (2) acute onset of hypotension, bronchospasm, or laryngeal symptoms within minutes to hours after exposure to a known or suspected allergen, which may occur without typical skin/mucosal symptoms.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to the components or excipients of omalizumab; 2. Children who are experiencing an acute exacerbation of severe allergic reaction or who have concurrent acute bronchial asthma; 3. Patients who are receiving other targeted drug treatments; 4. Patients using beta-blockers for treatment; 5. Patients with missing clinical data or who have withdrawn prematurely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of severe allergic reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function;Fractional exhaled nitric oxide (FeNO);Pediatric Asthma Quality of Life Questionnaire (PAQLQ);Childhood Asthma Control Test (C-ACT);Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ);Nasal symptom score and visual analog scale (VAS);Dermatology Life Quality Index (DLQI);Urticaria Activity Score (UAS);Eczema Area and Severity Index (EASI); | — |
Countries
China
Contacts
Public ContactShi Rui Ming
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed