HIV
Conditions
Interventions
Observation group:none
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Confirmed HIV infection; 3. Planning to start antiretroviral therapy (ART); 4. Regular follow-up for over 4 years, divided into two groups based on CD4 T cell levels: (1) IR: HIV patients on ART for more than 4 years with CD4 T cell count monitored above 350/µL, defined as good immune reconstitution. They are also further divided into subgroups based on the range of CD4 T cell levels. (2) INR: Patients who have received ART for more than 4 years, with peripheral blood viral load below the detection limit (viral load <50 copies/mL) for over 3 years, but CD4 T cell counts still persistently below 350/µL. 5. Voluntarily participating in this study, able to follow the study protocol to complete all follow-up requirements, and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with combined HBV/HCV infection; 2. Those already diagnosed with other types of immune deficiencies; 3. Patients who have received immunosuppressive or immunomodulatory treatment within the past 6 months before screening; 4. Those with opportunistic infections or AIDS-related malignancies; 5. Pregnant or breastfeeding women; 6. Other patients already diagnosed with serious gastrointestinal, cardiovascular, or cerebrovascular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Construction of a Clinical Prediction Model for Immune Reconstitution Failure in AIDS Patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Temporal changes in immune function; | — |
Countries
China
Contacts
Public ContactTang Jia
Shanghai Public Health Clinical Center
Outcome results
None listed