Painless gastroscopy in high-risk populations in a high-altitude hypoxic environment
Conditions
Interventions
Group A: Combined Anesthesia with Conventional Nasal Oxygen :Lidocaine Aerosol Inhalation + Remifentanil + Etomidate + Conventional Nasal Cannula Oxygen Therapy
Group B: Combined Anesthesia with High-Flow Nasal Oxygen :Lidocaine Aerosol Inhalation + Remifentanil + Etomidate + High-Flow Nasal Oxygen (HFNC)
Sponsors
People's Hospital of Hainan Tibetan Autonomous Prefecture, Qinghai Province
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 - 80 years. 2.Long-term residents of high-altitude regions (altitude >= 2500 m) who meet at least one of the following high-risk conditions: COPD; OSA; obesity (BMI =>=28 kg/m²); aged >= 60 years; 3.Informed consent: able to understand the study content and sign written informed consent.
Exclusion criteria
Exclusion criteria: 1.Acute coronary syndrome, decompensated heart failure (NYHA class IV), or uncontrolled severe arrhythmias. 2.Acute respiratory failure, acute respiratory infection, end-stage pulmonary disease, active asthma exacerbation, acute exacerbation of COPD, high-altitude pulmonary edema, or acute high-altitude illness. 3.Hepatic failure or decompensated liver disease; end-stage renal disease or renal failure requiring dialysis. 4.Active upper gastrointestinal bleeding, high-risk esophageal/gastric variceal bleeding, gastric emptying disorders, or high aspiration risk precluding non-intubated anesthesia. 5.History of allergy to anesthetics or medications (e.g., propofol, etomidate, remifentanil) or to high-flow nasal oxygen devices. 6.Pregnant or lactating women. 7.Concurrent participation in other clinical studies that may interfere with the results of this study. 8.Other conditions judged by the investigator to be unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Hypoxemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Severe Hypoxemia;Incidence of Airway Interventions; | — |
Countries
China
Contacts
Public ContactLiu Lifeng
People's Hospital of Hainan Tibetan Autonomous Prefecture, Qinghai Province
Outcome results
None listed