None
Conditions
Interventions
Experimental Group:After skin closure at the end of the surgery, the surgeon used a sterile syringe to draw 266 mg (20 mL) of undiluted liposomal bupivacaine. The needle was inserted subcutaneously at
Control Group:Twenty milliliters of 0.25% bupivacaine was drawn up using a syringe. The needle was inserted subcutaneously at a position 1 cm away from the edge of the incision, and no blood was aspir
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 2. ASA classification I-III 3. No mental illness or cognitive impairment 4. Patients scheduled for elective thoracoscopic surgery 5. All patients were informed about the study before being included and voluntarily signed the informed consent form
Exclusion criteria
Exclusion criteria: 1. People who are allergic to general anesthetics, local anesthetics, or painkillers; 2. People who are dependent on painkillers; 3. People with a history of chronic pain; 4. People with severe heart, liver, or kidney problems; 5. People who recently had an active infection or blood clotting issues; 6. People who refuse to participate in the clinical trial; 7. People who have trouble speaking or understanding and can’t complete the NRS (Numeric Pain Rating Scale).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time-weighted area under the curve (AUC) of Numerical Rating Scale (NRS) pain scores at rest within 72 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative Dosages of Sufentanil and Remifentanil;The time-weighted area under the curve (AUC) of Numerical Rating Scale (NRS) pain scores during movement within 72 hours postoperatively;Within 72 hours postoperatively: the number of effective presses of patient-controlled intravenous analgesia (PCIA);the time to first rescue analgesia, and the consumption of opioid analgesics;Postoperative 24-hour Quality of Recovery-15 (QoR-15) score and analgesic satisfaction;;Time to first ambulation after surgery, total postoperative hospital stay duration, and total length of hospital stay;;Incidence of postoperative complications and adverse reactions; | — |
Countries
China
Contacts
Public ContactQi Dunyi
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed