Non-Alcoholic Fatty Liver Disease
Conditions
Interventions
The control group:None
Sponsors
Henan Children's Hospital, Zhengzhou Children's Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 17 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the case group: 1. Ages between 6 and 17 years old; 2. The diagnosis of NAFL (non-alcoholic fatty liver) and NASH (non-alcoholic steatohepatitis) refers to the NAFLD Activity Score announced by the NASH Clinical Research Network of the National Institutes of Health. Liver fibrosis is referred to the METAVIR Scoring System. Inclusion criteria for the control group: 1. Ages between 6 and 17 years old; 2. Fatty liver is excluded by liver ultrasound examination.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the case group: Exclude those with a drinking habit, liver diseases caused by pharmacological and chemical factors, and specific diseases that can lead to fatty liver in children. Exclusion criteria for the control group: 1.Exclude liver diseases caused by pharmacological and chemical factors, including glucocorticoids, traditional Chinese medicine preparations, and dietary supplements, etc.; 2.chronic liver diseases, including hepatitis B, hepatitis C, autoimmune liver diseases, hereditary and metabolic liver diseases, etc.; 3.hypothalamic-pituitary lesions, thyroid diseases; 4. those with poor general conditions, severe infections, severe hepatic or renal insufficiency, or cardiovascular and cerebrovascular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SHH?HSP90ß?IL-6?IL-1ß?TNF-a;; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose, blood lipids, fasting blood insulin, 25-hydroxyvitamin D3, and various biochemical indicators of liver function.;Height, weight, waist circumference, BMI (Body Mass Index), blood pressure.; | — |
Countries
China
Contacts
Public ContactZhou Fang
Henan Children's Hospital, Zhengzhou Children's Hospital
Outcome results
None listed