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Exploring the Clinical Value of HE4/WFDC2 Expression in Therapeutic Efficacy Assessment and Prognostic Prediction of Colorectal Cancer

Exploring the Clinical Value of HE4/WFDC2 Expression in Therapeutic Efficacy Assessment and Prognostic Prediction of Colorectal Cancer

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600129468
Enrollment
Unknown
Registered
2026-08-05
Start date
2026-08-12
Completion date
Unknown
Last updated
2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary colorectal adenocarcinoma

Interventions

Case series:None

Sponsors

The First Affiliated Hospital of Shantou University Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Pathologically confirmed primary colorectal adenocarcinoma; 2. Received neoadjuvant therapy (including chemoradiotherapy and/or immunotherapy) followed by radical surgery; 3. Had complete clinicopathological data and documented therapeutic response evaluation records; 4. Had intact and available paraffin-embedded tumor tissue specimens.

Exclusion criteria

Exclusion criteria: 1. Had a prior history of other malignancies; 2. Received unplanned preoperative therapy; 3. Had postoperative pathological confirmation of residual lesions that precluded efficacy evaluation; 4. Had specimens of inadequate quality (e.g., severe autolysis or excessive necrotic area).

Design outcomes

Primary

MeasureTime frame
tumor regression;

Secondary

MeasureTime frame
HE4/WFDC2 protein expression level;

Countries

China

Contacts

Public ContactLiang Yuanke

The First Affiliated Hospital of Shantou University Medical College

ykliang12345@163.com+86 754 8890 5186

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 25, 2026