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Association Between Trendelenburg Position and Postoperative Neurological Complications in Frail Elderly Patients Undergoing Non-Cardiac Surgery and the Mediating Role of Multimodal Cerebral Monitoring Indicators: A Prospective Observational Cohort Study

Association Between Trendelenburg Position and Postoperative Neurological Complications in Frail Elderly Patients Undergoing Non-Cardiac Surgery and the Mediating Role of Multimodal Cerebral Monitoring Indicators: A Prospective Observational Cohort Study

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600129466
Enrollment
Unknown
Registered
2026-08-05
Start date
2026-04-23
Completion date
Unknown
Last updated
2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative neurological complications

Interventions

Control group (Trendelenburg position =2 hours):None

Sponsors

Shandong Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1.Age >= 65 years; 2.Scheduled for elective surgery; 3.Anticipated requirement for the Trendelenburg position during surgery; 4.Written informed consent signed by the patient or their authorized representative; 5.American Society of Anesthesiologists (ASA) physical status classification ?-?.

Exclusion criteria

Exclusion criteria: 1.Emergency surgery; 2.A known history of severe neurological diseases (e.g., dementia, Parkinson’s disease, severe sequelae of stroke, severe traumatic brain injury, epilepsy, etc.); 3.Preoperative diagnosis of obstructive sleep apnea syndrome (OSA) without standardized treatment, or other known severe sleep disorders; 4.Severe visual or hearing impairment precluding effective communication; 5.Symptomatic severe carotid artery stenosis (>70%) or intracranial vascular lesions; 6.Presence of contraindications to transcranial Doppler (TCD) or near-infrared spectroscopy (NIRS) monitoring (e.g., frontal skin damage, skull defect, etc.).

Design outcomes

Primary

MeasureTime frame
The incidence of postoperative sleep disorders;The incidence of long-term cognitive dysfunction;The incidence of postoperative delirium;Incidence of complex neurological complications;

Secondary

MeasureTime frame
Incidence of stroke;

Countries

China

Contacts

Public ContactWang Gongming

Shandong Provincial Hospital

tagmwang1971@163.com+86 15168863629

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 25, 2026