Sepsis
Conditions
Interventions
Sepsis Group (Group S) :None
Sepsis-Related Cardiac Dysfunction Group (Group SC) :None
Sponsors
Zhangzhou Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the Sepsis Group (Group S) (1) Meeting the diagnostic criteria for sepsis 3.0 established in 2016; (2) Age >= 18 years; (3) Confirmed absence of other cardiac diseases; (4) Echocardiography showing an ejection fraction (EF) >= 50%; (5) Voluntary participation of the patient. 2. Inclusion criteria for the Sepsis-Related Cardiac Dysfunction Group (Group SC) (1) Compliance with the diagnostic criteria for sepsis 3.0; (2) Age >= 18 years; (3) Septic patients with elevated cardiac troponin (cTn) > 99th percentile of the upper reference limit (URL) or positive high-sensitivity troponin (hs-cTn) test; (4) Echocardiography showing an ejection fraction (EF) = 18 years; (2) Informed consent obtained from the participant or their legal representative.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for the Sepsis Group (Group S) (1) Patients aged < 18 years; (2) History of organ failure (i.e., heart failure, respiratory failure, liver failure, renal failure, etc.); (3) History of immune system diseases; (4) History of hematological diseases; (5) History of malignancy; (6) Patients unwilling to participate in the study. 2.Exclusion criteria for the Sepsis-Related Cardiac Dysfunction Group (Group SC) (1) Patients aged < 18 years; (2) History of organ failure (i.e., heart failure, respiratory failure, liver failure, renal failure, etc.); (3) History of immune system diseases; (4) History of hematological diseases; (5) History of malignancy; (6) Patients unwilling to participate in the study. 3.Exclusion criteria for the Healthy Control Group (Group C) (1) Patients aged < 18 years; (2) History of organ failure (i.e., heart failure, respiratory failure, liver failure, renal failure, etc.); (3) History of immune system diseases; (4) History of hematological diseases; (5) History of malignancy; (6) Patients unwilling to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ribonucleic acid;Metabolite; | — |
Secondary
| Measure | Time frame |
|---|---|
| White blood cell count( WBC count); Lymphocyte Count;Platelet Count;Serum Creatinine;Total Bilirubin (TB);Aspartate Transaminase (AST);Procalcitonin (PCT);C-reactive Protein (CRP);Interleukin-6 (IL-6);Lactic Acid (Lac);cTnI: Cardiac Troponin I (cTnI);BNP: B-type Natriuretic Peptide (BNP);Echocardiographic parameters (Ejection Fraction (EF));Duration of Mechanical Ventilation;Average Daily Dose of Norepinephrine (or Noradrenaline);28-day mortality rate;General data ; | — |
Countries
China
Contacts
Public ContactHuang Qiaowen
Zhangzhou Affiliated Hospital of Fujian Medical University
Outcome results
None listed