refractory obsessive-compulsive disorder
Conditions
Sponsors
The Affiliated Brain Hospital , Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age between 16 and 65 years (inclusive); 2.Meet the preliminary diagnostic criteria for obsessive-compulsive disorder in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5); 3.Meet the definition of treatment-refractory illness, defined as no response to adequate and sufficient courses (>8 weeks) of at least two anti-obsessive-compulsive medications with different mechanisms of action; 4.Y-BOCS total score = 16; 5.The subject and his/her family have been informed of the study and voluntarily provided written informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of severe somatic diseases or organic diseases of the liver, kidney, brain or other organs; 2.Comorbidity with epilepsy, craniocerebral injury or severe neurological disorders; 3.Other primary Axis I diagnoses (such as schizophrenia, acute episode of bipolar disorder, substance abuse), except that comorbid depression or anxiety disorders are permitted; 4.Females who are pregnant or lactating; 5.Medical contraindications to ECT, MST or general anesthesia, such as the presence of a cardiac pacemaker, cochlear implant, or metallic implants in the head; 6.Received any neuromodulation therapy within the past 6 months, including transcranial direct current stimulation, repetitive transcranial magnetic stimulation, ECT, and transcranial alternating current stimulation; 7.History of alcohol or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Y-BOCS scores from baseline to after the 12th treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in neurocognitive function scores; | — |
Countries
China
Contacts
Public ContactNing Yuping
The Affiliated Brain Hospital , Guangzhou Medical University
Outcome results
None listed