Malignant tumors
Conditions
Interventions
Index test:Early and standard 18F-FDG PET/CT imaging. Participants will receive 18F-FDG by group and undergo PET/CT at 40 minutes, followed by a second PET scan on the same scanner at 60 minutes, to c
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 80 years, with no restriction on sex; 2. Patients with clinically suspected or newly diagnosed tumors who are scheduled to undergo PET/CT for diagnosis and staging; tumor patients who are scheduled to undergo PET/CT for follow-up or suspected recurrence and restaging; or tumor patients who are scheduled to undergo PET/CT for response evaluation after systemic treatment; 3. Patients who can provide a definitive pathological diagnosis before or after PET/CT examination, with an interval of no more than 4 weeks between pathological diagnosis and PET/CT examination, and who have not received anti-tumor treatment during this interval; 4. Women of childbearing potential with no pregnancy plan within 3 months; 5. Patients with good compliance, clear consciousness, and the ability to move and take care of themselves; 6. A stratified enrollment strategy will be adopted, with approximately 5%-10% of the total enrolled participants being high-BMI patients (BMI >29 kg/m²); 7. Participants who agree to participate in this clinical study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Poor general condition and inability to cooperate with the examination; 2. Mental disorders or intellectual developmental delay resulting in poor compliance and inability to cooperate with the examination; 3. Fasting blood glucose >11 mmol/L; 4. Pregnant women; 5. Patients with claustrophobia; 6. Other conditions deemed by the investigators to be unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion detection sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number and detection rate of malignant lesions;Five-point visual score for lesion 18F-FDG uptake;Lesion standardized uptake values (SUVmax, SUVpeak, and SUVmean);Background-tissue signal-to-noise ratio;Interobserver agreement;Lesion-to-background ratios;Background-tissue mean standardized uptake value and standard deviation (SUVmean and SD); | — |
Countries
China
Contacts
Public ContactShi Hongcheng
Zhongshan Hospital, Fudan University
Outcome results
None listed