Pulmonary hypertension
Conditions
Interventions
Hypophysin group:After induction of anesthesia, the initial concentration of pituitary lutein was pumped to maintain, and the maximum concentration was adjusted to 0.04 U/min. The dosage was adjusted
Norepinephrine group:After induction of anesthesia, noradrenaline was administered for 4-12ug/min maintenance, and the dosage was adjusted according to the patient's systemic blood pressure to maintai
Sponsors
Wuxi People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old; 2.ASA ?~?, Patients intending lung transplantation under general anesthesia.
Exclusion criteria
Exclusion criteria: 1.Known hypersensitivity to any study medication; 2.Presence of severe cerebrovascular disease, severe hepatic dysfunction (Child-Pugh class C), or renal dysfunction requiring renal replacement therapy; 3.Preoperative administration of angiotensin-converting enzyme inhibitor (ACEI); 4.Inability to provide written informed consent. 5.Patients with severe pulmonary hypertension; 6.Cardiac function grade (NYHA) = 3; 7.Oxygen saturation < 90% under oxygen inhalation; 8.Intolerance to conscious pulmonary artery floating catheter placement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure;Pulmonary Artery Pressure;Ratio of pulmonary resistance to systemic resistance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urine volume;Cardiac index;Heart rate;Eccentricity Index;Blood electrolyte concentration;Partial Pressure of Oxygen;Partial Pressure of Carbon Dioxide; | — |
Countries
China
Contacts
Public ContactChen Min
Wuxi People’s Hospital
Outcome results
None listed