Atrial fibrillation, moderate to severe periodontitis
Conditions
Interventions
Non-periodontitis group:None
Group with periodontitis who haven't received periodontal treatment:None
Periodontitis patients receiving basic periodontal treatment:None
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age: =18 years old; 2.Diagnosed with atrial fibrillation; 3.Planned for first catheter ablation; 4.At least 10 natural teeth; 5.No systematic periodontal treatment received in the past; 6.No smoking habit or smoking less than 10 cigarettes per day; 7.Subject informed consent.
Exclusion criteria
Exclusion criteria: 1.History of atrial fibrillation ablation or cardiac surgery; valvular heart disease (moderate to severe mitral or aortic valve lesions) or post-mechanical valve replacement; left atrial thrombus; severe heart failure (NYHA Class IV) or left ventricular ejection fraction 3 times the upper limit of normal, eGFR < 30ml/min); 6.Women who are pregnant, planning to become pregnant, or breastfeeding; 7.Patients who require long-term or intermittent antibiotic use and receive drug treatments known to affect periodontal conditions (such as amoxicillin); 8.Use of any systemic or topical immunosuppressants within the past 6 months; 9.At least one of the following conditions occurs: acute oral infection, acute oral pain (including pulpitis), suspicious oral mucosal lesions, severe oral inflammation unrelated to periodontal disease, or ongoing orthodontic treatment; 10.Participate in other clinical trials related to drugs or medical devices at the same time; 11.Subjects with severe difficulties in comprehending written and spoken grammar; 12.Persons with other circumstances that may affect the conduct of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periodontal related indicators;Baseline clinical data;Atrial fibrillation-related outcome indicators;Biological Sample Testing Indicators; | — |
Countries
China
Contacts
Public ContactJiang Shengjie
Peking University Hospital of Stomatology
Outcome results
None listed