Patients with gallbladder diseases requiring laparoscopic cholecystectomy
Conditions
Interventions
Oliceridine Group:Oliceridine Combined with Transversus Abdominis Plane Block for Multimodal Analgesia
Sufentanil Group:Sufentanil Combined with Transversus Abdominis Plane Block for Multimodal Analgesia
Sponsors
Shaanxi 215 Hospital of nuclear industry
Eligibility
Sex/Gender
Female
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Female, age 18-64 years; 2. American Society of Anesthesiologists (ASA) grades I to III; 3. Planned to undergo elective laparoscopic cholecystectomy; 4. Postoperative nausea and vomiting (PONV) risk score (Apfel score) >= 2 points (including at least two items "female" and "non-smoker").
Exclusion criteria
Exclusion criteria: 1. Long-term or regular use of opioid analgesics or antiemetic drugs. 2. Known allergy to local anesthetics (e.g., ropivacaine), or contraindications to transversus abdominis plane block (e.g., infection at puncture site, coagulation dysfunction). 3. Pregnant or lactating women. 4. Severe hepatic or renal insufficiency (e.g., Child-Pugh class C, or estimated glomerular filtration rate eGFR < 30 mL/min/1.73m²). 5. History of severe neurological or psychiatric disorders that may interfere with the assessment of pain or nausea. 6. Inability to comprehend the study content or refusal to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome:Postoperative quality recovery score (QoR-15) at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first get out of bed after surgery;Incidence and severity of postoperative nausea and vomiting (PONV);Total dose of remifentanil during the operation;Postoperative VAS pain score at rest and on coughing;Outcome:Rate of rescue antiemetic use;Incidence of postoperative adverse events;Preoperative and 48 hours postoperative quality recovery score (QoR-15);Postoperative length of hospital stay; | — |
Countries
China
Contacts
Public ContactChen Peng
Shaanxi 215 Hospital of nuclear industry
Outcome results
None listed