Vascular Cognitive Impairment
Conditions
Interventions
1Hz-taVNS:Patients remained seated and received transcutaneous vagus nerve stimulation (tVNS) concurrently with routine one-on-one computer-assisted cognitive training. After degreasing the left conch
25Hz-taVNS:Patients remained seated and received transcutaneous vagus nerve stimulation (tVNS) concurrently with routine one-on-one computer-assisted cognitive training. After degreasing the left conc
Sponsors
The Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for Vascular Cognitive Impairment (VCI); 2. Have a Clinical Dementia Rating (CDR) classification of Mild or Moderate, with a total score = 7 on the Hachinski Ischemic Scale (HIS); 6. Score <= 17 on the Hamilton Depression Scale (HAMD); 7. Voluntarily agree to participate in this clinical observational study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Dementia attributed to other etiologies, including but not limited to brain tumor, other neurodegenerative diseases (e.g., Alzheimer's disease), demyelinating disorders, major systemic medical conditions, or metabolic abnormalities; 2. Presence of severe neurological deficits (e.g., aphasia, severe visual or auditory impairment) that would preclude adequate cooperation with study assessments; 3. History of severe substance abuse, including alcohol dependence, illicit drug use, or misuse of psychoactive medications; 4. Concurrent severe cardiac, hepatic, renal, or other major organ system diseases, or clinically unstable medical conditions; 5. Current participation or participation within the past two weeks in another clinical trial involving cognitive interventions or assessments; 6. Current use of medications specifically intended to enhance or improve cognitive function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment-Basic Chinese Version ,MoCA-B;EEG parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental state examination,MMSE;the Hopkins Verbal Learning Test-Revised,HVLT-R;Boston Naming Test,BNT;Clock Drawing Test, CDT4;functional activities questionnaire,FAQ;Tail making teat,TMT; | — |
Countries
CHINA
Contacts
Public ContactWang Ran
The Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Outcome results
None listed