Head and Neck Squamous Cell Carcinoma
Conditions
Interventions
Observation group:None
Sponsors
Shanghai Ninth Peoples Hospital,Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Histopathologically confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC). 2.Age >= 18 years; patients who understand and voluntarily sign the written informed consent, are willing to participate in the study, and agree to comply with scheduled follow-up. 3.Availability of corresponding fresh and formalin-fixed paraffin-embedded (FFPE) tumor tissue samples, as well as blood, saliva, and stool specimens. 4.Availability of complete baseline clinical data, including but not limited to age, sex, TNM stage, HPV infection status, smoking and alcohol consumption history, treatment regimen, and treatment response evaluation records.
Exclusion criteria
Exclusion criteria: 1.Known diagnosis of any autoimmune disease (e.g., systemic lupus erythematosus, rheumatoid arthritis). 2.History of other prior malignancies. 3.Known uncontrolled severe infections (e.g., HIV, active hepatitis, active tuberculosis) or severe immunodeficiency disorders. 4.Prior hormone therapy or immunotherapy before study enrollment. 5.Presence of psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of blood-related biomarkers and related immune cells;Detection of microorganisms and metabolites in saliva and fecal samples;Composition of the tumor immune microenvironment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinically relevant data, including basic information (name, age, gender, native place), past medical history, tumor TNM stage, treatment plan, etc.; | — |
Countries
China
Contacts
Public ContactZhang Wuchang
Shanghai Ninth Peoples Hospital,Shanghai JiaoTong University School of Medicine
Outcome results
None listed