Early graft dysfunction after kidney transplantation, including delayed graft function, acute rejection, CNI nephrotoxicity, and prolonged acute tubular necrosis.
Conditions
Interventions
Gold Standard:The criteria for DGF is whether dialysis is needed within the first week after surgery. The reference standard for acute rejection (AR) is a kidney transplant biopsy that meets the Banff
if a biopsy can’t be done, a combined diagnosis based on clinical signs, serology, and treatment response is used. The reference standard for non-rejection acute injury (Non-AR) is a biopsy showing no
Index test:Smart Assistant Model for Early Recovery and Damage Prediction of Transplanted Kidneys
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult recipients aged 18 years or older undergoing first allogeneic kidney transplantation; 2. Recipients receiving tacrolimus-based maintenance immunosuppressive therapy after transplantation; 3. Written informed consent obtained, or waiver of informed consent approved when applicable.
Exclusion criteria
Exclusion criteria: 1. Recipients of combined multi-organ transplantation, such as combined liver-kidney transplantation; 2. Patients with severe preoperative hepatic dysfunction (Child-Pugh class C), which may affect indoxyl sulfate metabolism; 3.Patients with severely incomplete clinical data or loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of delayed graft function (DGF);Diagnostic performance: sensitivity, specificity, positive/negative predictive values (PPV/NPV), best cut-off value; | — |
Countries
China
Contacts
Public ContactYao Fu
Wuxi people’s Hospital
Outcome results
None listed