gastroesophageal varices in Liver Cirrhosis
Conditions
Interventions
Tiglidipine Group:The induction dose of tiglidipine 1 mg combined with propofol 1.2–2 mg/kg
the maintenance dose of propofol (each bolus dose is 1/3–1/2 of the initial dose).
Sufentanil Group:The induction dose of sufentanil 0.1 µg/kg combined with propofol 1.2–2 mg/kg
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in the study and sign the informed consent form; 2. Aged 18–70 years; 3. Body Mass Index (BMI) of 18–30 kg/m^2; 4. Undergoing elective Endoscopic Variceal Ligation (EVL) (non-emergency hemostatic surgery); 5. Child-Pugh liver function classification of Grade A or B (Grade C excluded); 6. American Society of Anesthesiologists (ASA) physical status classification = 92%; 9. Estimated Glomerular Filtration Rate (eGFR) >= 60 ml/min/1.73 m^2.
Exclusion criteria
Exclusion criteria: 1. Long-term use of opioid/benzodiazepine drugs (> 3 months) or use within 48 hours; 2. Hepatic encephalopathy >= Stage II (West-Haven criteria); 3. Active upper gastrointestinal bleeding (hematemesis or melena) within 24 hours; 4. Diuretic-refractory refractory ascites; 5. Difficult airway (Mallampati classification >= Grade ?); 6. Alcohol dependence (AUDIT score >= 8 points); 7. History of hypersensitivity to the study drugs; 8. Presence of indications for emergency tracheal intubation (e.g., respiratory failure, risk of asphyxia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting/Dynamic NRS Pain Score;Number of rescue analgesia administrations;Recovery Quality Indicators;Anesthesia effect evaluation indicators; | — |
Countries
China
Contacts
Public ContactJiang Ke
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed