Diabetic Retinopathy
Conditions
Interventions
Standard Panretinal Photocoagulation Group:532 nm multi?spot laser, 300 µm spot, 0.02 s, grade II–III burns, 1–2 spot intervals, 3–4 sessions over 2 weeks, macular?sparing, total 1200–1600 spots, nasa
Modified Panretinal Photocoagulation Group: Same laser settings as Group A, but with nasal sparing enlarged to 2–3 optic disc diameters (PD, ~3000–4500 µm), and the spared nasal spots equally redistri
Sponsors
General Hospital of Central Theater Command, People's Liberation Army (PLA)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years with treatment-naïve severe nonproliferative diabetic retinopathy or early proliferative diabetic retinopathy who required panretinal photocoagulation (PRP); 2. Clear ocular media sufficient for high-quality fundus imaging; 3. Provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. Glaucoma, uveitis, macular disease, or optic neuropathy; 2. Significant vitreous hemorrhage or media opacity; 3. Vitreoretinal interface abnormalities; 4. Prior history of panretinal photocoagulation (PRP) or intravitreal injection (except for cataract surgery alone performed more than 3 months ago); 5. History of ocular trauma; 6. OCTA image quality index <5.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Superficial capillary plexus vessel density;Deep capillary plexus vessel density;Full retinal capillary plexus vessel density;Choriocapillaris flow density;Choroidal vascular volume;Choroidal vascularity index;Central subfield thickness;Incidence of vitreous hemorrhage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity;Static perimetry mean deviation;Contrast sensitivity;Multifocal electroretinography;Retinal nerve fiber layer thickness; | — |
Countries
China
Contacts
Public ContactChen Cong
General Hospital of Central Theater Command, People's Liberation Army (PLA)
Outcome results
None listed