Postoperative pain after major open abdominal surgery in the elderly
Conditions
Interventions
Tegileridine Group:Postoperative analgesia with Tegileridine via patient-controlled analgesia (PCA).
Control Group:Postoperative analgesia with Sufentanil via patient-controlled analgesia (PCA).
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years; 2.Elective surgery planned with a laparotomy incision and an anticipated surgical duration of >=2 hours, including open radical/resection procedures involving the stomach, liver, gallbladder, pancreas, spleen, colon, or rectum; 3.American Society of Anesthesiologists (ASA) physical status classification I–III; 4.Capable of understanding and completing the OBAS, HADS, RCSQ, and QoR-15 assessment scales; 5.Preoperative Mini-Cog score >= 3; 6.Fully informed about the study protocol and voluntarily participating with signed informed consent;
Exclusion criteria
Exclusion criteria: 1.Allergy to study drugs; 2.Severe hepatic or renal dysfunction (Child-Pugh class C or requiring renal replacement therapy); 3.Long-term use of sedatives, antidepressants, or history of psychoactive substance abuse, including alcohol dependence; 4.History of severe central nervous system disorders, documented cognitive impairment, dementia, delirium, psychiatric illness, or language communication barriers; 5.Chronic pain, neuropathic pain, or long-term use of analgesics; 6.Inability to complete pain assessment; 7.Morbid obesity with BMI > 35 kg/m^2;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative OBAS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and frequency of rescue analgesia;OBAS single-time scoring;Additional rescue opioid consumption expressed as morphine equivalents;QoR-15 scores;Incidence of respiratory depression or excessive sedation;Incidence of PONV;HADS Score;RCSQ scores;Postoperative complications;Incidence of Delirium;Length of postoperative hospital stay;All-cause 30-day mortality;health-related quality of life; | — |
Countries
China
Contacts
Public ContactLiu Huayue
The First Affiliated Hospital of Soochow University
Outcome results
None listed