Lung Cance
Conditions
Interventions
Experimental group:4D-CBCT-guided radiotherapy using an abdominal compression bridge.
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 to 80 years with pathologically or radiologically confirmed pulmonary malignant tumors (primary or metastatic). 2.Patients scheduled to undergo radical radiotherapy or oligometastasis-directed radiotherapy, and deemed suitable for lattice radiotherapy (LRT) after multidisciplinary discussion. 3.Tumors predominantly located in the lower lung lobe (especially adjacent to the diaphragm), with a motion amplitude of =5 mm in the SI direction as measured on free-breathing 4D-CBCT. 4.Karnofsky Performance Status (KPS) score >= 70. 5.Able to understand the study information and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe COPD (FEV1 < 50% predicted) or other restrictive lung diseases that would not tolerate any abdominal compression. 2.Major abdominal/thoracic surgery within 3 months, uncontrolled ascites, hernia, abdominal infection, bowel obstruction, significant abdominal tenderness, or pregnancy. 3.Patients with obvious intestinal obstruction, abdominal tenderness, abdominal aortic aneurysm, or other conditions that may increase the risk of complications due to elevated intra-abdominal pressure. 4.Concurrent uncontrolled malignancy. 5.History of prior radiotherapy to any other organ in the thoracic cavity. 6.Presence of cardiac pacemakers or other metallic prosthetic implants that may be adversely affected by high-energy radiation or may interfere with radiation dose distribution to the target volume. 7.Presence of severe comorbidities that may potentially interfere with the delivery of radiotherapy. 8.Presence of psychiatric disorders or cognitive impairment that may preclude compliance with the treatment procedures. 9.Unable to understand the study, or unwilling/unable to give informed consent. 10.Other conditions that, in the opinion of the investigator, would render the patient unsuitable for participation in the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Technical success rate, defined as the proportion of treatment fractions achieving a respiratory motion reduction rate (RRM) of =30%.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of lung volume receiving =10 Gy;Conformity index;D98% of planning target volume;Percentage of lung volume receiving =20 Gy;D95% of planning target volume;Percentage of lung volume receiving =5 Gy;Mean dose to the heart;Maximum dose to the spinal cord;Gradient index; | — |
Countries
China
Contacts
Public ContactXu Xiaoyan
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed