Postoperative sleep disorder
Conditions
Interventions
Esketamine group:Esketamine
Remimazolam group:Remimazolam
The remimazolam combined with esketamine group:remimazolam combined with esketamine
Propofol group:Propofol
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective gynecological surgery under general anesthesia; 2.Aged over 18 years; 3.ASA physical status ?–?; 4.BMI 18.5–27.9 kg/m^2;
Exclusion criteria
Exclusion criteria: 1. Patients refuse to participate in the study; 2. Preoperative Pittsburgh Sleep Quality Index (PSQI) 7; 3. Recent history of substance abuse or drug addiction; 4.Contraindications or allergy to esketamine and remimazolam; 5.Cognitive dysfunction or inability to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Athens Insomnia Scale,AIS;Pittsburgh Sleep Quality Index (PSQI); | — |
Secondary
| Measure | Time frame |
|---|---|
| intraoperative dosage of vasoactive drugs;perioperative consumption of opioids;perioperative adverse reactions;intraoperative hemodynamic changes;Visual Analogue Scale (VAS); | — |
Countries
China
Contacts
Public ContactGuanglei Wang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed