allergic rhinitis
Conditions
Interventions
Healthy Control Group:None
Sponsors
Hanzhong Central Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for AR as defined in the Chinese Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2022, revised edition); 2. Aged 5–75 years, regardless of sex; 3. Positive skin prick test (SPT) to at least one allergen and/or positive serum specific IgE test, or positive nasal provocation test.
Exclusion criteria
Exclusion criteria: 1. Age under 5 years or over 75 years; 2. Concomitant chronic rhinosinusitis, nasal polyps, or anatomical abnormalities of the nasal cavity; 3. Use of systemic or intranasal corticosteroids, antihistamines, antibiotics, or immunotherapy within the 4 weeks prior to enrollment; 4. Concomitant systemic inflammatory diseases, autoimmune diseases, or immunodeficiency disorders; 5. Failure to provide signed informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean fluorescence intensity (MFI) of M2 macrophage marker CD163; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD206 expression percentage and MFI in M2 macrophages;Concentrations of IL-10, TGF-ß, and TNF-a in culture supernatants; | — |
Countries
China
Contacts
Public ContactZhuqian
Hanzhong Central Hospital
Outcome results
None listed