Radial artery spasm
Conditions
Interventions
Experimental group:nitroglycerin-coated catheter therapy
control group:traditional radial artery injection therapy
Sponsors
Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Volunteer to sign a written informed consent form, fully understanding the research purpose, process, and potential risks; 2.Age range from 18 to 80 years old, gender is not limited; 3.Patients diagnosed with radial artery spasm (RAS) via radial artery angiography exhibit local vascular stenosis (diameter reduction =30%), significantly increased resistance to catheter advancement, or obstruction of contrast medium passage; 4.Pain at the puncture site (Visual Analogue Scale, VAS = 4) or interruption of the procedure due to spasm; 5.Hemodynamically stable (systolic blood pressure =90 mmHg and heart rate =50 beats per minute), with no severe comorbidities affecting the implementation of intervention;
Exclusion criteria
Exclusion criteria: 1.Hypersensitivity to the components of nitroglycerin; 2.individuals with severe coagulation dysfunction or a tendency towards active bleeding; 3.women in pregnancy or lactation period; 4.Patients with anatomical abnormalities such as tortuosity, calcification, or occlusion of the radial artery; 5.patients with severe hepatic and renal dysfunction, uncontrolled hypertension, or severe cardiovascular disease; 6.Recent users of potent CYP3A4 inhibitors or PDE5 inhibitors; 7.individuals with mental disorders, cognitive impairments, or those unable to cooperate with follow-up visits; 8.Patients who, according to the comprehensive assessment of the researcher, are deemed unsuitable for participation in this trial (such as those with complex conditions, short expected survival, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of Successful Catheter Passage on First Attempt; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score of spasm-related pain after intervention;Total time for catheter passing through spastic segment;Incidence of operation-related complications; | — |
Countries
China
Contacts
Public ContactShifei Wang
Nanfang Hospital, Southern Medical University
Outcome results
None listed