Adult Patients with Bilateral Cryptorchidism and Non-obstructive Azoospermia
Conditions
Interventions
Testicular fixation group:None
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male, over 18 years old at the time of surgery or the first study of related diagnosis and treatment. 2. Previously diagnosed as bilateral cryptorchidism, and having not completed bilateral testicular descent treatment before seeking medical attention in adulthood. 3. Before the operation, the diagnosis of non-obstructive azoospermia was met, that is, no sperm was found in at least two semen analyses and centrifugation sediment tests, and a clear obstructive cause was ruled out in combination with clinical assessment. 4. During the period from March 1, 2005 to September 30, 2023, those who underwent surgical assessment, orchiopexy or related fertility preservation pathway management at Shanghai First People's Hospital. 5. Have a semen reexamination record or a postoperative micro-TESE record that can be used to determine the sperm acquisition after the operation.
Exclusion criteria
Exclusion criteria: 1. Only unilateral cryptorchidism, or the medical records cannot confirm bilateral lesions. 2. The main cause of the disease is obstructive azoospermia, or the existence of evaluable sperm acquisition before the operation makes it impossible to determine the postoperative outcome. 3. Key exposure variables or primary outcome data are missing and cannot be completed after medical record verification. 4. There are serious record conflicts, and after verification by the research team, the main diagnosis, surgery or outcome still cannot be confirmed. 5. Those whose previous medical records have been explicitly refused for scientific research analysis in their medical records or hospital records.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative fertility-usable sperm recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion and time of sperm detection in postoperative semen;The acquisition of micro-TESE sperm in patients with persistent azoospermia after surgery;The live birth outcome after using the obtained sperm;Testicular tumor events recorded in the medical records during the follow-up period;Changes in the status of biochemical hypogonadism before and after the operation;Changes in the status of biochemical hypogonadism before and after the operation; | — |
Countries
China
Contacts
Public ContactLi Peng
Shanghai General Hospital
Outcome results
None listed