Enlarged tonsils / adenoids
Conditions
Interventions
Younger Children Group (Group Y): 1–5 years old:The dose for the younger children group was set at Oliceridine 35 µg/kg , with a dose adjustment step of 2 µg/kg. If a child exhibited a positive cardi
if no positive response occurred, the dose was decreased by 2 µg/kg. The trial for each group was terminated after the seventh crossover point between positive and negative responses was reached.
Older Children Group (Group E): 6–14 years old:The dose for the older children group was set at Oliceridine 40 µg/kg, with a dose adjustment step of 2 µg/kg. If a child exhibited a positive cardiovas
Sponsors
Guangzhou Women and Children Medical Center Liuzhou Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. Age 1–14 years old; 2. ASA classification I–II; 3. Children undergoing tonsil and/or adenoid removal under general anesthesia (tracheal intubation).
Exclusion criteria
Exclusion criteria: 1. Children who are allergic to the components of Oseli; 2. Children with acute upper respiratory tract infection symptoms before the operation; children with a history of bronchial asthma; 3. Children with existing or potential difficult airway conditions as assessed before the operation; 4. Children with related mental or neurological disorders and difficult to evaluate the analgesic effect; 5. Children with a history of chronic pain or long-term use of painkillers; 6. Children with other conditions that the researchers consider unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxalidine inhibits the ED50 and ED95 of the cardiovascular response to tracheal intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of cough after injection of oxalidine;Success rate of sedation;Hemodynamic changes before and after intubation;In the PACU, the PAED and FLACC scores; | — |
Countries
China
Contacts
Public ContactLingyu Wang
Guangzhou Women and Children Medical Center Liuzhou Hospital
Outcome results
None listed