Non-thyroidal illness syndrome
Conditions
Interventions
Control group:Conventional treatment
Levothyroxine treatment group:Conventional treatment combined with levothyroxine tablets
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years and <=90 years; 2. Critically ill patients admitted to the ICU or MICU; 3. Diagnosis of non-thyroidal illness syndrome, defined as no history of primary thyroid or pituitary disease, decreased serum T3 or FT3, normal or decreased TSH, and normal or decreased T4 or FT4, with primary thyroid disease excluded according to clinical assessment; 4. Written informed consent provided by the patient or by the legally authorized representative/guardian.
Exclusion criteria
Exclusion criteria: 1. Age 90 years; 2. History of thyroid disease, including goiter; 3. Hypothalamic disease, pituitary disease, malignant tumor, or hematological disease; 4. Pregnant or perinatal women, or patients with psychiatric disorders; 5. Inability to receive enteral administration, including patients with acute gastrointestinal injury grade III or IV; 6. Acute myocardial infarction, acute myocarditis, acute pancarditis, severe arrhythmia, or acute heart failure at baseline; 7. Patients considered unsuitable for participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of organ function improvement; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality;Serum TSH level;Serum T3 level;Serum T4 level;Serum FT3 level;Serum FT4 level;SOFA score;Levothyroxine-related adverse events; | — |
Countries
China
Contacts
Public ContactChuming Fan
The First People's Hospital of Yunnan Province
Outcome results
None listed