Acute ischemic stroke due to occlusion of major anterior circulation vessels
Conditions
Interventions
SLBC group (Super Large Lumen Catheter Aspiration Group):Preferably use an extra-large-bore suction catheter with an inner diameter (ID) of >=0.080 inch for simple suction thrombectomy.
SRT group (stent thrombectomy group):Preferably, use a stent-assisted thrombectomy device to remove the thrombus
the use of catheters with an extra-large lumen, as defined in this study, is not permitted in this group.
Sponsors
Shanghai Sixth People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Clinically diagnosed with acute ischemic stroke, confirmed by preoperative imaging to have occlusion of the intracranial internal carotid artery and/or the M1 segment of the middle cerebral artery; 3.mRS score of 0–1 prior to the current stroke episode; 4.Baseline NIHSS score >=6; 5.ASPECT score >= 3; 6.Time from symptom onset to initiation of endovascular treatment (arterial puncture and catheterization) < 24 hours; symptom onset defined as "last seen normal"; 7.Treatment with intravenous thrombolysis and/or mechanical thrombectomy according to local guidelines, without delay in mechanical thrombectomy due to intravenous thrombolysis; 8.Written informed consent signed by the patient or a legal representative.
Exclusion criteria
Exclusion criteria: 1.Imaging shows acute or subacute intracranial hemorrhage (excluding micro-hemorrhagic foci); 2.Imaging indicates intracranial tumors (excluding meningiomas with a diameter less than 2 cm) or tumor-induced space-occupying effects such as midline shift; 3.Cerebral embolism caused by infection and bacterial endocarditis; 4.Consideration of chronic arteriosclerotic stenosis and occlusion of the responsible vascular lesion; 5.Prior imaging suggests the lesion as a dissection onset; 6.Previous responsible vascular intracranial aneurysms and vascular malformations; 7.Existing diseases within 6 months that are life-threatening and cannot be evaluated within 3 months; 8.Pregnant women, mental disorders, severe liver and kidney dysfunction, severe heart failure; 9.Participating simultaneously in another clinical drug or device study; 10.Metastatic tumors; 11.Systemic infections; 12.Other situations deemed unsuitable for participation in this study by the investigators.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Change in stroke severity (NIHSS score) at 7 days postoperatively or upon discharge (whichever occurs first).;mRS 0-2 ratio;Postoperative mRS scores at 90 ± 7 days under other binomial classifications (0–1 vs. 2–6; 0–3 vs. 4–6; 0–4 vs. 5–6; 0–5 vs. 6);Changes in stroke severity (NIHSS score) at 24 hours postoperatively; | — |
Primary
| Measure | Time frame |
|---|---|
| mRS ordinal score; | — |
Countries
China
Contacts
Public ContactZhu Yueqi
Shanghai Sixth People’s Hospital
Outcome results
None listed