cervical cancer
Conditions
Interventions
DNA methylation sequencing group:None
RNA sequencing group:None
16S rDNA sequencing group:None
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 18-65; 2. History of sexual activity; 3. No sexual activity within 48 hours prior to the examination and meeting any of the following conditions:1)No vaginal douching or medication within 48 hours;2)No use of antibiotics or antifungal drugs within 30 days, and no use of vaginal suppositories within 14 days; 4. No vaginal examination was performed and it was not the menstrual period; 5. Voluntarily participate in research projects and sign informed consent forms;
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. History of cervical surgery (such as hysterectomy); 3. Those with a history of cervical and vaginal lesions treatment; 4. Patients with other malignant tumors; 5. Patients with blood system or digestive system diseases; 6. History of previous radiotherapy and chemotherapy; 7. Those with reproductive tract abnormalities who cannot undergo a cervical examination; 8. Taking demethylating drugs (such as decitabine, azacitidine, hydrazine, procainamide, procaine, curcumin, etc.) within two months; 9. Those who withdraw midway through the program; 10. Those with incomplete clinical information and related examination information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cervical lesions grade;Detection efficacy of methylation biomarkers;Typing of human papillomavirus;Detection efficacy of RNA biomarkers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cervical cytology test results;Detection efficacy of vaginal microbial biomarkers; | — |
Countries
China
Contacts
Public ContactQing Li
Xiangya Hospital Central South University
Outcome results
None listed