Gastrointestinal tumor
Conditions
Interventions
Tegileridine Group:Tegileridine
Sponsors
Changzhi people's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 65–80 years, any gender, scheduled for laparoscopic radical resection of gastric, colon or rectal cancer; 2.ASA physical status ?–? and NYHA cardiac function classification ?–?; 3.Clear consciousness and capable of completing QoR-40 questionnaire, NRS pain assessment and follow-up visits; 4.Basically normal hepatic, renal and coagulation function; 5.Voluntarily sign informed consent and comply with the whole study and follow-up procedures; 6.Expected moderate to severe postoperative pain requiring analgesia;
Exclusion criteria
Exclusion criteria: 1.Patients with allergy to tegileridine, oliceridine or any opioids; 2.Severe respiratory dysfunction (severe chronic obstructive pulmonary disease, respiratory failure) or NYHA cardiac function class ? and above; 3.Severe hepatic and renal failure; 4.Mental disorders or cognitive impairment that hinder questionnaire assessment and follow-up; 5.Administration of opioid analgesics, glucocorticoids or immunosuppressants within one week before surgery; 6.Coagulopathy, active gastrointestinal bleeding, or intraoperative blood loss = 500 mL; 7.Confirmed or suspected gastrointestinal obstruction, including paralytic ileus;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Recovery-40 (QoR-40) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Analgesic satisfaction score;Total length of hospital stay;C-reactive protein (CRP);Neutrophil-to-lymphocyte ratio (NLR);Time to first flatus, defecation and first ambulation;PCA presses and rescue analgesia rate within 48 h postoperatively;Numeric Rating Scale (NRS) pain score;Incidence of adverse events within 48 hours postoperatively;Intraoperative mean arterial pressure (MAP) and heart rate (HR); | — |
Countries
China
Contacts
Public ContactXiaoyan Ma
Changzhi people's Hospital
Outcome results
None listed