Autoimmune hepatitis often presents with fatigue, poor appetite, jaundice, and hepatosplenomegaly, and may have an acute or insidious onset. Primary biliary cholangitis predominantly affects middle-aged women, with fatigue and pruritus as early typical symptoms
Conditions
Interventions
Gold Standard:AIH Diagnostic Criteria: According to experts from the Hepatology Branch of the Chinese Medical Association, combined with the latest advancements, the guidelines for the diagnosis and t
2. Positive AMA/AMA-M2, or if AMA is negative, other PBC-specific autoantibodies such as sp100 or gp210 are positive
3. Histological evidence suggesting non-suppurative destructive cholangitis and interlobular bile duct injury.
PSC Diagnostic Criteria: PSC can be classified into large duct type and small duct type.
Index test:Imaging examintion?ALP ? GGT AMA/AMA-M2 ?IgG4
Sponsors
Chongqing University Three Gorges Hospital(Chongqing Three Gorges Central Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75 years, with no gender restriction; 2. Meeting the clinical diagnostic criteria; 3. Good patient compliance and willingness to participate in the investigation; 4. Full informed consent obtained from the patient or family member, with a signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Alcoholic liver disease, non-alcoholic fatty liver disease, viral hepatitis, drug-induced and toxic liver injury; and other diseases that may cause severe liver injury; 2. Hepatitis, cirrhosis, and liver cancer caused by other etiologies; 3. Acute cerebrovascular accidents and extrahepatic end-stage diseases; 4. Pregnant women, parturients, or lactating women; 5. Diabetes mellitus; 6. Other conditions deemed unsuitable for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Basic demographic data; 2) Hematological parameters: ? Serological markers: FGF21, FGF19, KLB, etc.; ? Complete blood count parameters; ? Coagulation parameters;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactGuicheng Wu
Chongqing University Three Gorges Hospital(Chongqing Three Gorges Central Hospital)
Outcome results
None listed