Severe heart/lung failure.
Conditions
Interventions
B Group:Pump-controlled reinfusion
A Group:Citrate-stored Blood Bag Recovery and Transfusion
C Group:Blood donation
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, regardless of gender; 2. Received VV, VA or V-AV ECMO treatment due to severe heart/lung failure, and the treatment duration was >= 24 hours; 3. After assessment by the medical team, it was determined that the patient could successfully be removed from ECMO (the indication for removal is in line with the ELSO guidelines); 4. Before we remove the ventilator, the hemoglobin (Hb) level should be 6 to 10 g/dL (excluding patients with high Hb levels who do not require blood transfusion); 5. The patient or their legal representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Presence of severe active bleeding prior to or during ECMO weaning (e.g., intracranial hemorrhage, massive gastrointestinal bleeding, etc.); 2.Received allogeneic blood products within 24 hours before the removal of the ventilator; 3.Combined with severe coagulation dysfunction (such as congenital deficiency of coagulation factors, coagulation disorder caused by severe liver disease, etc.); 4.Combine malignant tumors, end-stage kidney disease (not acute kidney injury), immunodeficiency diseases and other underlying conditions; 5.Pregnant or lactating women; 6.It is expected that death will occur within 48 hours after the removal of the ventilator. 7.Refused to participate in this study; 8.A bloodstream infection had occurred before the removal of the ventilator and the administration of blood transfusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute increase in hemoglobin;Allogeneic packed red blood cell transfusion volume within 72 hours after weaning; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic variation level of hemoglobin;Dynamic changes in platelet count;Health economics indicators;Coagulation function Indicator;Inflammation Indicator;Clinical outcomes;Hemodynamics; | — |
Countries
China
Contacts
Public ContactHu Bo
Zhongnan Hospital of Wuhan University
Outcome results
None listed