Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.COPD group: aged 40–80 years, meeting the GOLD diagnostic criteria (FEV1/FVC < 0.7 after inhalation of bronchodilators). 2.AECOPD group: meeting the diagnostic criteria for AECOPD and seeking medical treatment due to acute exacerbation of symptoms; 3. Stable COPD group: Meets the GOLD criteria and is in a stable state (with no acute exacerbation in the past 4 weeks); 4. Healthy group: Has no chronic respiratory diseases, normal lung function, and is matched with the case group in terms of age, gender, and smoking history.
Exclusion criteria
Exclusion criteria: 1.Complicated with other major respiratory diseases; 2.Complicated with severe cardiac, hepatic and renal insufficiency; 3.Suffering from malignant tumors or autoimmune diseases; 4.Unable to cooperate with completing questionnaire surveys or sample collection;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung function;Personal exposure environment of PM2.5-O3-CO-CO2-VOCs-T-P;Exosome miRNA sequencing and proteomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline data (demographics, smoking history, disease history, medication history);Symptom scores (CAT, mMRC);History of acute exacerbation; | — |
Countries
China
Contacts
Public ContactLong Xuan
Shanghai Tenth People's Hospital
Outcome results
None listed